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Pramoxine hydrochloride is a common, over-the-counter anti-itch ingredient that provides temporary relief from itching caused by insect bites, minor skin irritations, poison ivy, sunburn and more. It is not a steroid like hydrocortisone, which works to reduce inflammation. Steroid-based creams are generally not recommended for long-term use,1 but pramoxine hydrochloride is a safe, steroid-free, itch-relieving option that can be used as needed.

Important Things to Know about Pramoxine Hydrochloride

  • Pramoxine hydrochloride is a local anesthetic, which means it numbs the skin where it is applied to help minimize the sensation of itching and pain.2 By temporarily numbing the skin, pramoxine hydrochloride provides temporary relief from itching caused by insect bites, minor skin irritations, sunburn and more.Clinical studies have shown that pramoxine hydrochloride begins working in as little as two minutes, and its effects last for up to eight hours.4

  • Pramoxine hydrochloride is found in concentrations of 0.5% - 1% in over-the-counter (OTC) itch-relief lotions and creams. These products can be applied as needed up to three or four times daily.

  • No, pramoxine hydrochloride is not an antihistamine. It is a local anesthetic that numbs the skin to minimize itching.

  • Although pramoxine hydrochloride is generally well-tolerated, it may cause dryness, redness, swelling, burning, stinging or pain in the area it is applied. If you experience any severe symptoms and they do not subside, it’s best to contact your doctor.5

  • Pramoxine hydrochloride is a beneficial ingredient for anyone experiencing itching due to minor irritations, insect bites, sunburn or rashes due to poison ivy. Do not use pramoxine hydrochloride on children under the age of two unless directed by a physician.

  • When using pramoxine hydrochloride for relief from itching due to minor skin irritation, it can be helpful to incorporate ingredients that help maintain the skin’s moisture and comfort, such as ceramides which help restore the skin’s natural barrier.

  • Pramoxine hydrochloride can be used to help relieve itching on the face and body.

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